Susan Santangelo, Sc.D. Address: Massachusetts General Hospital Harvard Medical School 149 13th Street, 10th Floor Charlestown, MA 02129 Phone Number: (617) 726-7876 Email: ssantangelo@partners.org

Dr. Santangelo is a genetic epidemiologist who was educated at Wellesley College and the Harvard School of Public Health. Her graduate training was supervised by Drs. Ming Tsuang, David Pauls, and Neil Risch. Formerly at New England Medical Center and Tufts School of Medicine, she joined the Psychiatric and Neurodevelopmental Genetics Unit at MGH in 2002. Her work involves determining the genetic architecture underlying various psychiatric disorders and other disorders with complex inheritance. She has studied Tourette's syndrome and obsessive compulsive disorder, autism, bipolar disorder, schizophrenia, attention deficit disorder, smoking and nicotine addiction, and age-related macular degeneration.

She is Assistant Professor at both the Harvard Medical School, and the Harvard School of Public Health. She is Co-Director of the Training Program in Psychiatric Epidemiology and Biostatistics at the Harvard School of Public Health, where she has been a faculty member since 1994.

Dr. Santangelo was the recipient of a Career Development Award from the National Institute of Mental Health ('Phenotype Delineation and Genetic Modeling of Autism': K21 MH01338) from 1995-2001. She received a grant from The Medical Foundation to conduct a pilot study entitled, 'Using Extremely Discordant Sib-Pairs to Search for Autism Genes,' from 1997-1999. This study is still ongoing, with funding from the March of Dimes Foundation.

Dr. Santangelo's techniques include Parametric ('model-dependent') and non-parametric ('model-free') linkage analysis, case-control and family based association analysis, heritability estimation, quantitative trait linkage analysis, and endophenotype measurement and analysis, standard biostatistical analyses.

Dr. Santangelo's goals are to elucidate the genetic architecture underlying several different diseases with complex inheritance.

Dr. Santangelo's current research efforts focus on autism, smoking and nicotine addiction, Tourette syndrome, and age-related macular degeneration.